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The top five states ranked with the lowest effective tax rate on new investment are: (1) Maine (3.0%); (2) Oregon (3.8%); (3) Ohio (4.4%); (4) Wisconsin (4.5%); and (5) Illinois (4.6%).

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Notable defense contractors include Goodyear Tire and Rubber Company in Akron, Lockheed Martin in Akron, which won a contract to develop a space-ship in 2003 and produces the vertical launch ASROC missile, Columbus-based Zyvex Performance Materials develops the Piranha Unmanned Surface Vessel.Gravitational Energy Corporation, located in Cuyahoga Falls, proliferates Gravity Assisted Power (GAP) machines in cooperation with Dri Powder, LLC to the military.Makino's Global Titanium Research and Development Center is located in Mason.Nextant Aerospace has manufacturing facilities at the Cuyahoga County Airport.The Air Force estimates that Wright-Patterson’s annual economic impact on the Dayton region is .1 billion.

Ohio had three city-regions in the top 30 biotech locations in the country, with Cleveland-Akron ranked #20, Columbus #22, and Cincinnati #28.

The overall economic impact of the bioscience industry in Ohio, including healthcare, amounted to 8.2 billion in 2007, representing 15.7% of Ohio's economic output.

Biotech research and development employs directly 12,415 residents, while agricultural bioscience contributed the largest economic impact, at .7 billion.

The United States Department of Defense currently maintains a large Supply Center in Whitehall, a suburb of Columbus.

Wright-Patterson Air Force Base, located in Dayton, and partially named for the Wright Brothers from Ohio who are generally credited with inventing the airplane, employs 27,400 residents.

In 2009, Governor Ted Strickland designated Dayton as Ohio's aerospace innovation hub, the first such technology hub in the state.